Intracellular study of human epileptic cortex: In vitro maintenance of epileptiform activity?

Abstract

Intracellular recordings were obtained in the in vitro slice preparation from neurons of lateral and mesial temporal cortex removed from human epileptics suffering from intractable temporal lobe seizures. Spontaneous rhythmic synoptic events, which were capable of triggering action potential discharge, were observed in many neurons, particularly in mesial tissue slices. Such activity may reflect the epileptogenic capacity of this human cortex.